2005-12-4 · Ca2 i in each Ca domain and release increases with a high-power dependence on Ca influx because of a high degree of Ca cooperativity. However prolonging presynaptic spikes or using depolarizing pulses of increasing amplitude increases
1996-10-1 · In all myocyte classes generation of the Ca2 spikes was modulated by basal Ca2 i which in turn was influenced by the influx of Ca2 through L-type Ca2 channels of the plasmalemma. 2. Conduit and resistance myocytes responded distinctly to hypoxia.
2021-4-23 · The role of the cytoskeleton in regulating Ca2 release has been explored in epithelial cells. Trains of local Ca2 spikes were elicited in pancreatic acinar cells by infusion of inositol trisphosphate through a whole cell patch pipette and the Ca2 -dependent Cl- current spikes were recorded. The spikes were only transiently inhibited by cytochalasin B an agent that acts on microfilaments.
2019-10-29 · A. Low-Threshold Ca2 Spikes and Burst Firing The identification of low-threshold spikes (LTS) in neurons suggested the existence of LVA channels an inference con-firmed by the work of many groups (7 17 165 169). Ca2 influx through LVA Ca2 channels engenders low-thresh-old spikes which in turn trigger a burst of action potentials
1998-11-1 · The spikes in this study however are related to the local release flux underlying these Ca 2 sparks collectively they provide a measurement of the release function underlying the conventional Ca 2 cyto transients (arising from the summation of the elemental Ca 2 sparks).
2021-4-23 · The role of the cytoskeleton in regulating Ca2 release has been explored in epithelial cells. Trains of local Ca2 spikes were elicited in pancreatic acinar cells by infusion of inositol trisphosphate through a whole cell patch pipette and the Ca2 -dependent Cl- current spikes were recorded. The spikes were only transiently inhibited by cytochalasin B an agent that acts on microfilaments.
2002-3-1 · In pancreatic acinar cells low threshold concentrations of acetylcholine (ACh) or cholecystokinin (CCK) induce repetitive local cytosolic Ca2 spikes in the apical pole while higher concentrations elicit global signals. We have investigated the process that transforms local Ca2 spikes to global Ca2 transients focusing on the interactions of multiple intracellular messengers.
1994-1-1 · Spikes might stimulate Ca2 -regulated transcription26-28 since transcriptional inhibitors have a similar effect24 29. The results implicate the activity of a signal-transduction cascade that drives the differen- tiation of these embryonic neurons (Fig. 2).
J Physiol 591.7 (2013) pp 1599–1612 1599 The Journal of Physiology Neuroscience Inhibition of dendritic Ca2 spikes by GABA B receptors in cortical pyramidal neurons is mediated by a direct G i/o-βγ-subunit interaction with Ca v1 channels Enrique Perez-Garci´ 1 2 Matthew E. Larkum 3 and Thomas Nevian1 4 1Department of Physiology University of Berne B¨uhlplatz 5 CH-3012 Bern Switzerland
2021-4-23 · The role of the cytoskeleton in regulating Ca2 release has been explored in epithelial cells. Trains of local Ca2 spikes were elicited in pancreatic acinar cells by infusion of inositol trisphosphate through a whole cell patch pipette and the Ca2 -dependent Cl- current spikes were recorded. The spikes were only transiently inhibited by cytochalasin B an agent that acts on microfilaments.
2005-7-7 · A Ca2 spike elicits a turn in the trajectory followed by a period of straight swimming ( turn-and-run ). The train of Ca2 spikes gives rise to repetitive loop-like movements. When sperm swim in a concentration gradient of the attractant the Ca2 spikes and the stimulus function are synchronized suggesting that precise timing of Ca2 spikes
The Ca2 spikes and swimming behavior of sperm from starfish and sea urchin are similar implying that the signaling pathway of chemotaxis has been conserved for almost 500 million years. ABThe events that occur during chemotaxis of sperm are only partly known. As an essential step toward determining the underlying mechanism we have
In neurons which showed spikes with low threshold addition of 25 μM Cd 2 disclosed a smaller and shorter regenerative response the low-threshold spike. Moreover the classical anode-break stimulation from -50/-60 mV uncovered isolated low-threshold spikes indicating a time- and voltage-dependent de-inactivating process.
2015-3-30 · Ca2 spikes are generated on different dendritic branches in the primary motor cortex of mice performing different motor learning tasks causing
2009-9-16 · Prolonged ca2 - e endent Afterhyperpolarizations in Hippocampal Neurons of Aged Rats Abstract. The po.ssibi1it.y that culcir4m is elevated in brain nertrons during aging animal for two spikes and one for three spikes (16). After two spikes there is a main etiect of
Ca2 j spikes that vary only in the decay phase (2 17 19 20). Such variations in the shape of Ca2 spikes. CELLULAR CALCIUM SIGNALING 1507 with different agonists is a widespread observation in many cell types. However there may be numerous dis-tinct underlying causes for
1997-1-15 · Agonists induce Ca 2 spikes waves and oscillations initiating at a trigger zone in exocrine acinar cells via Ca 2 release from intracellular Ca 2 stores. Using a low affinity ratiometric Ca 2 indicator dye benzothiazole coumarin (BTC) we found that high concentrations of agonists transiently increased Ca 2 concentrations to the micromolar range (>10 μM) in the trigger zone.
2014-2-20 · Using two-photon functional imaging of dendrites combined with whole-cell recordings in the mouse hippocampus in vivo Grienberger et al. identify multidendrite NMDA receptor-dependent Ca2 spikes as critical determinants of complex spike burst activity in CA1 pyramidal neurons.
2008-6-12 · Frequency Modulation of Synchronized Ca2 Spikes in Cultured Hippocampal Networks through G-Protein-Coupled Receptors Zhijun Liu 1 Lin Geng 1 Ruxin Li 1 Xiangping He 1 James Q. Zheng 2 and Zuoping Xie1 1Department of Biological Science and Biotechnology State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University Beijing China 100084 and
1996-10-1 · In all myocyte classes generation of the Ca2 spikes was modulated by basal Ca2 i which in turn was influenced by the influx of Ca2 through L-type Ca2 channels of the plasmalemma. 2. Conduit and resistance myocytes responded distinctly to hypoxia.
1992-11-1 · Cytosolic calcium signals evoked by the sulphydryl-group-oxidising agent thimerosal have been investigated in acutely isolated pancreatic acinar cells. Two techniques were employed for the assessment of the cytosolic free-calcium concentration ( Ca2 i) measurement of calcium-dependent chloride and non-specific cation currents (whole-cell patch-clamp recording) and microfluorimetry (fura
In neurons which showed spikes with low threshold addition of 25 μM Cd 2 disclosed a smaller and shorter regenerative response the low-threshold spike. Moreover the classical anode-break stimulation from -50/-60 mV uncovered isolated low-threshold spikes indicating a time- and voltage-dependent de-inactivating process.
1996-3-1 · Ca2 wave initiation and non-propagating Ca2 spikes occur as a result of localized Ca2 release from the more sensitive intracellular Ca2 stores. Using high spatial and temporal Ca2
4. The OG-5N image signal was localized to discrete release sites at the Z-line level of sarcomeres indicating that the local OG-5N spike arises from Ca 2 spikes at transverse (T) tubule-SR junctions (due to the imbalance between calcium ions entering the cytosol and the buffer molecules). 5.
2002-3-1 · In pancreatic acinar cells low threshold concentrations of acetylcholine (ACh) or cholecystokinin (CCK) induce repetitive local cytosolic Ca2 spikes in the apical pole while higher concentrations elicit global signals. We have investigated the process that transforms local Ca2 spikes to global Ca2 transients focusing on the interactions of multiple intracellular messengers.
Short (typically lasting no more than a few seconds) increases in cytosolic Ca2 concentration that periodically interrupts the stable resting level. Many Ca2 signals are delivered to cells as
1997-1-15 · Agonists induce Ca 2 spikes waves and oscillations initiating at a trigger zone in exocrine acinar cells via Ca 2 release from intracellular Ca 2 stores. Using a low affinity ratiometric Ca 2 indicator dye benzothiazole coumarin (BTC) we found that high concentrations of agonists transiently increased Ca 2 concentrations to the micromolar range (>10 μM) in the trigger zone.
1998-11-1 · The spikes in this study however are related to the local release flux underlying these Ca 2 sparks collectively they provide a measurement of the release function underlying the conventional Ca 2 cyto transients (arising from the summation of the elemental Ca 2 sparks).
2005-7-7 · A Ca2 spike elicits a turn in the trajectory followed by a period of straight swimming ( turn-and-run ). The train of Ca2 spikes gives rise to repetitive loop-like movements. When sperm swim in a concentration gradient of the attractant the Ca2 spikes and the stimulus function are synchronized suggesting that precise timing of Ca2 spikes
2020-11-12 · the Ca2 spikes is an important element in repetitively bring- ing back Ca2 Ii to the resting level. MATERIALS AND METHODS Fragments of mouse pancreas were digested by pure collagenase to obtain single acinar cells as previously described (11). A single cell loaded with fura-2 was maintained in a small (40-90 cell volumes)
2005-7-7 · The events that occur during chemotaxis of sperm are only partly known. As an essential step toward determining the underlying mechanism we have recorded Ca 2 dynamics in swimming sperm of marine invertebrates. Stimulation of the sea urchin Arbacia punctulata by the chemoattractant or by intracellular cGMP evokes Ca 2 spikes in the flagellum. A Ca 2 spike elicits a turn in the trajectory
1999-7-26 · The mechanisms of agonist-induced Ca 2 spikes have been investigated using a caged inositol 1 4 5-trisphosphate (IP 3) and a low-affinity Ca 2 indicator BTC in pancreatic acinar cells. Rapid photolysis of caged IP 3 was able to reproduce acetylcholine (ACh)-induced three forms of Ca 2 spikes local Ca 2 spikes and submicromolar (<1 μM) and micromolar (1–15 μM) global Ca 2 spikes (Ca
2005-7-7 · A Ca2 spike elicits a turn in the trajectory followed by a period of straight swimming ( turn-and-run ). The train of Ca2 spikes gives rise to repetitive loop-like movements. When sperm swim in a concentration gradient of the attractant the Ca2 spikes and the stimulus function are synchronized suggesting that precise timing of Ca2 spikes
2008-6-12 · Frequency Modulation of Synchronized Ca2 Spikes in Cultured Hippocampal Networks through G-Protein-Coupled Receptors Zhijun Liu 1 Lin Geng 1 Ruxin Li 1 Xiangping He 1 James Q. Zheng 2 and Zuoping Xie1 1Department of Biological Science and Biotechnology State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University Beijing China 100084 and
2002-3-1 · In pancreatic acinar cells low threshold concentrations of acetylcholine (ACh) or cholecystokinin (CCK) induce repetitive local cytosolic Ca2 spikes in the apical pole while higher concentrations elicit global signals. We have investigated the process that transforms local Ca2 spikes to global Ca2 transients focusing on the interactions of multiple intracellular messengers.
The train of Ca 2 spikes gives rise to repetitive loop-like movements. When sperm swim in a concentration gradient of the attractant the Ca 2 spikes and the stimulus function are synchronized suggesting that precise timing of Ca 2 spikes controls navigation.
The Ca2 spikes and swimming behavior of sperm from starfish and sea urchin are similar implying that the signaling pathway of chemotaxis has been conserved for almost 500 million years. ABThe events that occur during chemotaxis of sperm are only partly known. As an essential step toward determining the underlying mechanism we have
We use a computational model to simulate dendritic Ca2 spikes and backpropagating action potentials (APs) in layer 5 pyramidal cells. We apply uniform EFs (less than 20 mV/mm) to the model and examine how they affect the threshold for activation of Ca2 spikes. We show that the effects of weak field on synaptically evoked Ca2 spikes depend
In neurons which showed spikes with low threshold addition of 25 μM Cd 2 disclosed a smaller and shorter regenerative response the low-threshold spike. Moreover the classical anode-break stimulation from -50/-60 mV uncovered isolated low-threshold spikes indicating a time- and voltage-dependent de-inactivating process.
2021-7-17 · Transformation of local Ca2 spikes to global Ca2 transients the combinatorial roles of multiple Ca2 releasing messengers. EMBO J 21 909-919 2002. PMID 11867519. Carafoli E. Intracellular calcium homeostasis. Annu Rev Biochem 56 395-433 1987. PMID 3304139. Chandrasekhar R Alzayady KJ Wagner LE 2nd and Yule DI. Unique Regulatory
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